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Inhibition of CtBP1 activity by Akt-mediated phosphorylation

Pc2 (Cbx4) is a member of the chromobox family of polycomb proteins, and is a SUMO E3 ligase for the transcriptional corepressor, CtBP1. Here we show that both CtBP1 and Pc2 are phosphorylated by the kinase Akt1, which is activated by growth factor signaling via the PI3-kinase pathway. In the presen...

詳細記述

保存先:
書誌詳細
主要な著者: Merrill, Jacqueline C., Kagey, Michael H., Melhuish, Tiffany A., Powers, Shannon E., Zerlanko, Brad J., Wotton, David
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866129/
https://ncbi.nlm.nih.gov/pubmed/20361981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.03.048
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