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Inhibition of CtBP1 activity by Akt-mediated phosphorylation
Pc2 (Cbx4) is a member of the chromobox family of polycomb proteins, and is a SUMO E3 ligase for the transcriptional corepressor, CtBP1. Here we show that both CtBP1 and Pc2 are phosphorylated by the kinase Akt1, which is activated by growth factor signaling via the PI3-kinase pathway. In the presen...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2866129/ https://ncbi.nlm.nih.gov/pubmed/20361981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.03.048 |
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