Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α

Chuvash polycythemia, the first hereditary disease associated with dysregulated oxygen-sensing to be recognized, is characterized by a homozygous germ-line loss-of-function mutation of the VHL gene (VHL(R200W)) resulting in elevated hypoxia inducible factor (HIF)-1α and HIF-2α levels, increased red...

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Hauptverfasser: Yoon, Donghoon, Okhotin, David V., Kim, Bumjun, Okhotina, Yulia, Okhotin, Daniel J., Miasnikova, Galina Y., Sergueeva, Adelina I., Polyakova, Lydia A., Maslow, Alexei, Lee, Yonggu, Semenza, Gregg L., Prchal, Josef T., Gordeuk, Victor R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866078/
https://ncbi.nlm.nih.gov/pubmed/20140661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-010-0599-0
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