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Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

To study the mechanism of maintenance of polymorphism at major histocompatibility complex (MHC) loci, synonymous and nonsynonymous (amino acid-altering) nucleotide substitutions in the putative antigen-recognition site (included in the first domain of the MHC molecule) and other regions of human and...

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Autori principali: Hughes, A L, Nei, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1989
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC286598/
https://ncbi.nlm.nih.gov/pubmed/2492668
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