Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups

Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 −1639G>A improve dose prediction compared with algorithms based solely on clinical and demographic factors. However, these algorithms better capture dose variability among whites than Asians or blacks. Herein, we evaluate whether other VK...

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Hauptverfasser: Limdi, Nita A., Wadelius, Mia, Cavallari, Larisa, Eriksson, Niclas, Crawford, Dana C., Lee, Ming-Ta M., Chen, Chien-Hsiun, Motsinger-Reif, Alison, Sagreiya, Hersh, Liu, Nianjun, Wu, Alan H. B., Gage, Brian F., Jorgensen, Andrea, Pirmohamed, Munir, Shin, Jae-Gook, Suarez-Kurtz, Guilherme, Kimmel, Stephen E., Johnson, Julie A., Klein, Teri E., Wagner, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865873/
https://ncbi.nlm.nih.gov/pubmed/20203262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-255992
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