Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing

Warfarin is a widely used anticoagulant with a narrow therapeutic index and large interpatient variability in the dose required to achieve target anticoagulation. Common genetic variants in the cytochrome P450-2C9 (CYP2C9) and vitamin K–epoxide reductase complex (VKORC1) enzymes, in addition to know...

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Bibliographische Detailangaben
Hauptverfasser: Johnson, JA, Gong, L, Whirl-Carrillo, M, Gage, BF, Scott, SA, Stein, CM, Anderson, JL, Kimmel, SE, Lee, MTM, Pirmohamed, M, Wadelius, M, Klein, TE, Altman, RB
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187550/
https://ncbi.nlm.nih.gov/pubmed/21900891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.185
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