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Notch2 Activation in the Embryonic Kidney Depletes Nephron Progenitors
Successive activation of Wnt4 and Notch2 generates nephrons from the metanephric mesenchyme. Mesenchymal-to-epithelial transition requires Wnt4, and normal development of the proximal nephron (epithelia of glomeruli and proximal tubules) requires Notch2. It is unknown, however, whether Notch2 dictat...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Nephrology
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865736/ https://ncbi.nlm.nih.gov/pubmed/20299358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009040353 |
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