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Notch2 Activation in the Embryonic Kidney Depletes Nephron Progenitors

Successive activation of Wnt4 and Notch2 generates nephrons from the metanephric mesenchyme. Mesenchymal-to-epithelial transition requires Wnt4, and normal development of the proximal nephron (epithelia of glomeruli and proximal tubules) requires Notch2. It is unknown, however, whether Notch2 dictat...

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Detalhes bibliográficos
Main Authors: Fujimura, Sayoko, Jiang, Qing, Kobayashi, Chiyoko, Nishinakamura, Ryuichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865736/
https://ncbi.nlm.nih.gov/pubmed/20299358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009040353
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