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Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment
Alzheimer's disease is the most common form of dementia, affecting 26 million people worldwide. The Aβ peptide (39–43 amino acids) derived from the proteolytic cleavage of the amyloid precursor protein is one of the main constituents of amyloid plaques associated with disease pathogenesis and t...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865728/ https://ncbi.nlm.nih.gov/pubmed/20014445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.312 |
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