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Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment
Alzheimer's disease is the most common form of dementia, affecting 26 million people worldwide. The Aβ peptide (39–43 amino acids) derived from the proteolytic cleavage of the amyloid precursor protein is one of the main constituents of amyloid plaques associated with disease pathogenesis and t...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865728/ https://ncbi.nlm.nih.gov/pubmed/20014445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.312 |
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