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Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment

Alzheimer's disease is the most common form of dementia, affecting 26 million people worldwide. The Aβ peptide (39–43 amino acids) derived from the proteolytic cleavage of the amyloid precursor protein is one of the main constituents of amyloid plaques associated with disease pathogenesis and t...

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Main Authors: Robert, Remy, Streltsov, Victor A, Newman, Janet, Pearce, Lesley A, Wark, Kim L, Dolezal, Olan
格式: Artigo
語言:Inglês
出版: Wiley Subscription Services, Inc., A Wiley Company 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865728/
https://ncbi.nlm.nih.gov/pubmed/20014445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.312
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