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Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: Insights from molecular dynamics simulations

Protein aggregation into insoluble fibrillar structures known as amyloid characterizes several neurodegenerative diseases, including Alzheimer's, Huntington's and Creutzfeldt-Jakob. Transthyretin (TTR), a homotetrameric plasma protein, is known to be the causative agent of amyloid patholog...

Полное описание

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Библиографические подробности
Главные авторы: Rodrigues, J Rui, Simões, Carlos J V, Silva, Cândida G, Brito, Rui M M
Формат: Artigo
Язык:Inglês
Опубликовано: Wiley Subscription Services, Inc., A Wiley Company 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865717/
https://ncbi.nlm.nih.gov/pubmed/19937650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.289
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