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De novo structure generation using chemical shifts for proteins with high-sequence identity but different folds

Proteins with high-sequence identity but very different folds present a special challenge to sequence-based protein structure prediction methods. In particular, a 56-residue three-helical bundle protein (GA(95)) and an α/β-fold protein (GB(95)), which share 95% sequence identity, were targets in the...

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Detalles Bibliográficos
Main Authors: Shen, Yang, Bryan, Philip N, He, Yanan, Orban, John, Baker, David, Bax, Ad
Formato: Artigo
Idioma:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865713/
https://ncbi.nlm.nih.gov/pubmed/19998407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.303
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