Akt1 controls macrophage response to LPS by regulating microRNAs

MicroRNAs regulated by LPS target genes that contribute to the inflammatory phenotype. Here we show that Akt1, which is activated by LPS, differentially regulates miRNAs including let-7e, miR-155, miR-181c and miR125b. In silico analyses and transfection studies revealed that let-7e represses TLR4 w...

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Detalhes bibliográficos
Main Authors: Androulidaki, Ariadne, Iliopoulos, Dimitrios, Arranz, Alicia, Doxaki, Christina, Schworer, Steffen, Zacharioudaki, Vassiliki, Margioris, Andrew N., Tsichlis, Philip N., Tsatsanis, Christos
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865583/
https://ncbi.nlm.nih.gov/pubmed/19699171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.06.024
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