Akt1 controls macrophage response to LPS by regulating microRNAs

MicroRNAs regulated by LPS target genes that contribute to the inflammatory phenotype. Here we show that Akt1, which is activated by LPS, differentially regulates miRNAs including let-7e, miR-155, miR-181c and miR125b. In silico analyses and transfection studies revealed that let-7e represses TLR4 w...

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Bibliografske podrobnosti
Main Authors: Androulidaki, Ariadne, Iliopoulos, Dimitrios, Arranz, Alicia, Doxaki, Christina, Schworer, Steffen, Zacharioudaki, Vassiliki, Margioris, Andrew N., Tsichlis, Philip N., Tsatsanis, Christos
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865583/
https://ncbi.nlm.nih.gov/pubmed/19699171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.06.024
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