Reduced Nitric Oxide/cGMP Signaling Contributes to Vascular Inflammation and Insulin Resistance Induced by High Fat Feeding

OBJECTIVE: Diet-induced obesity (DIO) in mice causes vascular inflammation and insulin resistance that are accompanied by decreased endothelial-derived nitric oxide (NO) production. We sought to determine whether reduced NO-cGMP signaling contributes to the deleterious effects of DIO on the vasculat...

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Hlavní autoři: Rizzo, Norma O., Maloney, Ezekiel, Pham, Matilda, Luttrell, Ian, Wessell, Hunter, Tateya, Sanshiro, Daum, Guenter, Handa, Priya, Schwartz, Michael W., Kim, Francis
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865555/
https://ncbi.nlm.nih.gov/pubmed/20093624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.199893
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