Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

Most RNA viruses lack the mechanisms to recognize and correct mutations that arise during genome replication, resulting in quasispecies diversity that is required for pathogenesis and adaptation. However, it is not known how viruses encoding large viral RNA genomes such as the Coronaviridae (26 to 3...

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Main Authors: Eckerle, Lance D., Becker, Michelle M., Halpin, Rebecca A., Li, Kelvin, Venter, Eli, Lu, Xiaotao, Scherbakova, Sana, Graham, Rachel L., Baric, Ralph S., Stockwell, Timothy B., Spiro, David J., Denison, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865531/
https://ncbi.nlm.nih.gov/pubmed/20463816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000896
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