N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

BACKGROUND: Microglia provide continuous immune surveillance of the CNS and upon activation rapidly change phenotype to express receptors that respond to chemoattractants during CNS damage or infection. These activated microglia undergo directed migration towards affected tissue. Importantly, the mo...

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Detalhes bibliográficos
Main Authors: McHugh, Douglas, Hu, Sherry SJ, Rimmerman, Neta, Juknat, Ana, Vogel, Zvi, Walker, J Michael, Bradshaw, Heather B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865488/
https://ncbi.nlm.nih.gov/pubmed/20346144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-11-44
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