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Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs) that causes skeletal muscle paralysis. Familial forms of ALS are linked to mutations in the superoxide dismutase-1 (SOD1) gene. The mechanisms of human SOD1 (hSOD1) toxicity to MNs are unknown. We hypothe...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865380/ https://ncbi.nlm.nih.gov/pubmed/20223753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq106 |
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