Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a polyglutamine expansion in huntingtin. There are no treatments that are known to slow the neurodegeneration caused by this mutation. Mutant huntingtin causes disease via a toxic gain-of-function mechanism a...

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Main Authors: Rose, Claudia, Menzies, Fiona M., Renna, Maurizio, Acevedo-Arozena, Abraham, Corrochano, Silvia, Sadiq, Oana, Brown, Steve D., Rubinsztein, David C.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865373/
https://ncbi.nlm.nih.gov/pubmed/20190273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq093
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