Synphilin-1 attenuates neuronal degeneration in the A53T α-synuclein transgenic mouse model

Genetic alterations in α-synuclein cause autosomal dominant familial Parkinsonism and may contribute to sporadic Parkinson's disease (PD). Synphilin-1 is an α-synuclein-interacting protein, with implications in PD pathogenesis related to protein aggregation. Currently, the in vivo role of synph...

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Hlavní autoři: Smith, Wanli W., Liu, Zhaohui, Liang, Yideng, Masuda, Naoki, Swing, Debbie A., Jenkins, Nancy A., Copeland, Neal G., Troncoso, Juan C., Pletnikov, Mikhail, Dawson, Ted M., Martin, Lee J., Moran, Timothy H., Lee, Michael K., Borchelt, David R., Ross, Christopher A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865369/
https://ncbi.nlm.nih.gov/pubmed/20185556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq086
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