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Transcription-dependent Activation of Ataxia Telangiectasia Mutated Prevents DNA-dependent Protein Kinase-mediated Cell Death in Response to Topoisomerase I Poison

Camptothecin (CPT) is a topoisomerase I inhibitor, derivatives of which are being used for cancer chemotherapy. CPT-induced DNA double-strand breaks (DSBs) are considered a major cause of its tumoricidal activity, and it has been shown that CPT induces DNA damage signaling through the phosphatidylin...

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Detalhes bibliográficos
Main Authors: Sakasai, Ryo, Teraoka, Hirobumi, Takagi, Masatoshi, Tibbetts, Randal S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865312/
https://ncbi.nlm.nih.gov/pubmed/20304914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.101808
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