Llwytho...

Ataxia telangiectasia mutated‐dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor

Topoisomerase II alpha (TOP2A) has a crucial role in proper chromosome condensation and segregation. Here we report the interaction of TOP2A with ataxia telangiectasia mutated (ATM) and its phosphorylation in an ATM‐dependent manner after DNA damage. In vitro kinase assay and site‐directed mutagenes...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Sci
Prif Awduron: Tamaichi, Hiroyuki, Sato, Masaki, Porter, Andrew C. G., Shimizu, Toshiaki, Mizutani, Shuki, Takagi, Masatoshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657118/
https://ncbi.nlm.nih.gov/pubmed/23163762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12067
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