Ataxia telangiectasia mutated‐dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor

Topoisomerase II alpha (TOP2A) has a crucial role in proper chromosome condensation and segregation. Here we report the interaction of TOP2A with ataxia telangiectasia mutated (ATM) and its phosphorylation in an ATM‐dependent manner after DNA damage. In vitro kinase assay and site‐directed mutagenes...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Tamaichi, Hiroyuki, Sato, Masaki, Porter, Andrew C. G., Shimizu, Toshiaki, Mizutani, Shuki, Takagi, Masatoshi
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2013
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657118/
https://ncbi.nlm.nih.gov/pubmed/23163762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12067
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