Safety Studies on Intrahepatic or Intratumoral Injection of Oncolytic Vesicular Stomatitis Virus Expressing Interferon-β in Rodents and Nonhuman Primates

Toxicology studies were performed in rats and rhesus macaques to establish a safe starting dose for intratumoral injection of an oncolytic vesicular stomatitis virus expressing human interferon-β (VSV-hIFNβ) in patients with hepatocellular carcinoma (HCC). No adverse events were observed after admin...

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Autores principales: Jenks, Nathan, Myers, Rae, Greiner, Suzanne M., Thompson, Jill, Mader, Emily K., Greenslade, Andrew, Griesmann, Guy E., Federspiel, Mark J., Rakela, Jorge, Borad, Mitesh J., Vile, Richard G., Barber, Glen N., Meier, Thomas R., Blanco, Michael C., Carlson, Stephanie K., Russell, Stephen J., Peng, Kah-Whye
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2010
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865219/
https://ncbi.nlm.nih.gov/pubmed/19911974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.111
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