Titration of CD45 and Csk expression uncouples basal and inducible T cell receptor signaling during thymic development

The kinase-phosphatase pair Csk and CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn. T cell receptor (TCR) signaling and thymic development require CD45 expression but proceed constitutively in the absence of Csk. Here we show that relative...

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Hauptverfasser: Zikherman, Julie, Jenne, Craig, Watson, Susan, Doan, Kristin, Raschke, William, Goodnow, Christopher C., Weiss, Arthur
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865198/
https://ncbi.nlm.nih.gov/pubmed/20346773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.03.006
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