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Titration of CD45 and Csk expression uncouples basal and inducible T cell receptor signaling during thymic development
The kinase-phosphatase pair Csk and CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn. T cell receptor (TCR) signaling and thymic development require CD45 expression but proceed constitutively in the absence of Csk. Here we show that relative...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865198/ https://ncbi.nlm.nih.gov/pubmed/20346773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.03.006 |
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