ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria

Mycolic acids are essential for the survival, virulence and antibiotic resistance of the human pathogen Mycobacterium tuberculosis. Inhibitors of mycolic acid biosynthesis, such as isoniazid and ethionamide, have been used as efficient drugs for the treatment of tuberculosis. However, the increase i...

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Main Authors: Kurth, Daniel G., Gago, Gabriela M., de la Iglesia, Agustina, Bazet Lyonnet, Bernardo, Lin, Ting-Wan, Morbidoni, Héctor R., Tsai, Shiou-Chuan, Gramajo, Hugo
Format: Artigo
Sprog:Inglês
Udgivet: Microbiology Society 2009
Fag:
Physiology and Biochemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865140/
https://ncbi.nlm.nih.gov/pubmed/19423629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/mic.0.027714-0
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