ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria

Mycolic acids are essential for the survival, virulence and antibiotic resistance of the human pathogen Mycobacterium tuberculosis. Inhibitors of mycolic acid biosynthesis, such as isoniazid and ethionamide, have been used as efficient drugs for the treatment of tuberculosis. However, the increase i...

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Autori principali: Kurth, Daniel G., Gago, Gabriela M., de la Iglesia, Agustina, Bazet Lyonnet, Bernardo, Lin, Ting-Wan, Morbidoni, Héctor R., Tsai, Shiou-Chuan, Gramajo, Hugo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Microbiology Society 2009
Soggetti:
Physiology and Biochemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865140/
https://ncbi.nlm.nih.gov/pubmed/19423629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/mic.0.027714-0
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