Fragile X Mental Retardation Protein is Required for Synapse Elimination by the Activity-Dependent Transcription Factor MEF2

Fragile X Syndrome (FXS), the most common genetic form of mental retardation and autism, is caused by loss of function mutations in an RNA binding protein, Fragile X Mental Retardation Protein (FMRP). Patients’ neurons, as well as those of the mouse model, Fmr1 knockout (KO), are characterized by an...

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Autori principali: Pfeiffer, Brad E., Zang, Tong, Wilkerson, Julia R., Taniguchi, Makoto, Maksimova, Marina A., Smith, Laura N., Cowan, Christopher W., Huber, Kimberly M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864778/
https://ncbi.nlm.nih.gov/pubmed/20434996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.03.017
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