Sensitivity of Cancer Cells to Truncated Diphtheria Toxin

BACKGROUND: Diphtheria toxin (DT) has been utilized as a prospective anti-cancer agent for the targeted delivery of cytotoxic therapy to otherwise untreatable neoplasia. DT is an extremely potent toxin for which the entry of a single molecule into a cell can be lethal. DT has been targeted to cancer...

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Bibliographic Details
Main Authors: Zhang, Yi, Schulte, Wendy, Pink, Desmond, Phipps, Kyle, Zijlstra, Andries, Lewis, John D., Waisman, David Morton
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864767/
https://ncbi.nlm.nih.gov/pubmed/20463924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010498
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