Crystal Structure of the Neutralizing Llama V(HH) D7 and Its Mode of HIV-1 gp120 Interaction

HIV-1 entry into host cells is mediated by the sequential binding of the envelope glycoprotein gp120 to CD4 and a chemokine receptor. Antibodies binding to epitopes overlapping the CD4-binding site on gp120 are potent inhibitors of HIV entry, such as the llama heavy chain antibody fragment V(HH) D7,...

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Main Authors: Hinz, Andreas, Lutje Hulsik, David, Forsman, Anna, Koh, Willie Wee-Lee, Belrhali, Hassan, Gorlani, Andrea, de Haard, Hans, Weiss, Robin A., Verrips, Theo, Weissenhorn, Winfried
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864739/
https://ncbi.nlm.nih.gov/pubmed/20463957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010482
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