Cyclosporine A mediated protection against microvascular endothelial cell hyperpermeability is independent of calcineurin inhibition

BACKGROUND: Mitochondria mediated apoptotic signaling contributes to microvascular hyperpermeability. We hypothesized that cyclosporine A (CsA), that protects mitochondrial transition pores would attenuate hyperpermeability independent of its calcineurin inhibitory property. METHODS: Hyperpermeabili...

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Hauptverfasser: Childs, Ed W., Tharakan, Binu, Nurudeen, Suliat, Delmas, Thomas L., Hellman, Joseph, Christie, Tasheika, Hunter, Felicia A., Smythe, W. Roy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864542/
https://ncbi.nlm.nih.gov/pubmed/20359571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2009.11.002
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