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Cyclosporine A mediated protection against microvascular endothelial cell hyperpermeability is independent of calcineurin inhibition
BACKGROUND: Mitochondria mediated apoptotic signaling contributes to microvascular hyperpermeability. We hypothesized that cyclosporine A (CsA), that protects mitochondrial transition pores would attenuate hyperpermeability independent of its calcineurin inhibitory property. METHODS: Hyperpermeabili...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2864542/ https://ncbi.nlm.nih.gov/pubmed/20359571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2009.11.002 |
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