Inhibition of mesothelin-CA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: implications for cancer therapy

BACKGROUND: Mesothelin, a tumor differentiation antigen highly expressed in mesothelioma and ovarian cancer, is the receptor for CA-125 (MUC 16) and this interaction may play a role in tumor metastasis. MORAb-009 is a chimeric anti-mesothelin monoclonal antibody. METHODS: Twenty-four patients with m...

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Hauptverfasser: Hassan, Raffit, Schweizer, Charles, Lu, Kun F., Schuler, Barbara, Remaley, Alan T., Weil, Susan C., Pastan, Ira
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864325/
https://ncbi.nlm.nih.gov/pubmed/19744744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2009.07.016
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