High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239

Human and simian immunodeficiency viruses (HIV and SIV) downregulate major histocompatibility complex class I (MHC-I) molecules from the surface of infected cells. Although this activity is conserved across viral isolates, its importance in AIDS pathogenesis is not clear. We therefore developed an a...

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Détails bibliographiques
Auteurs principaux: Friedrich, Thomas C., Piaskowski, Shari M., León, Enrique J., Furlott, Jessica R., Maness, Nicholas J., Weisgrau, Kimberly L., Mac Nair, Caitlin E., Weiler, Andrea M., Loffredo, John T., Reynolds, Matthew R., Williams, K. Y., Klimentidis, Yann C., Wilson, Nancy A., Allison, David B., Rakasz, Eva G.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863841/
https://ncbi.nlm.nih.gov/pubmed/20219903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02452-09
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