High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239

Human and simian immunodeficiency viruses (HIV and SIV) downregulate major histocompatibility complex class I (MHC-I) molecules from the surface of infected cells. Although this activity is conserved across viral isolates, its importance in AIDS pathogenesis is not clear. We therefore developed an a...

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Hlavní autoři: Friedrich, Thomas C., Piaskowski, Shari M., León, Enrique J., Furlott, Jessica R., Maness, Nicholas J., Weisgrau, Kimberly L., Mac Nair, Caitlin E., Weiler, Andrea M., Loffredo, John T., Reynolds, Matthew R., Williams, K. Y., Klimentidis, Yann C., Wilson, Nancy A., Allison, David B., Rakasz, Eva G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863841/
https://ncbi.nlm.nih.gov/pubmed/20219903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02452-09
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