High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239

Human and simian immunodeficiency viruses (HIV and SIV) downregulate major histocompatibility complex class I (MHC-I) molecules from the surface of infected cells. Although this activity is conserved across viral isolates, its importance in AIDS pathogenesis is not clear. We therefore developed an a...

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Detalhes bibliográficos
Main Authors: Friedrich, Thomas C., Piaskowski, Shari M., León, Enrique J., Furlott, Jessica R., Maness, Nicholas J., Weisgrau, Kimberly L., Mac Nair, Caitlin E., Weiler, Andrea M., Loffredo, John T., Reynolds, Matthew R., Williams, K. Y., Klimentidis, Yann C., Wilson, Nancy A., Allison, David B., Rakasz, Eva G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863841/
https://ncbi.nlm.nih.gov/pubmed/20219903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02452-09
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