High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239

Human and simian immunodeficiency viruses (HIV and SIV) downregulate major histocompatibility complex class I (MHC-I) molecules from the surface of infected cells. Although this activity is conserved across viral isolates, its importance in AIDS pathogenesis is not clear. We therefore developed an a...

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Autors principals: Friedrich, Thomas C., Piaskowski, Shari M., León, Enrique J., Furlott, Jessica R., Maness, Nicholas J., Weisgrau, Kimberly L., Mac Nair, Caitlin E., Weiler, Andrea M., Loffredo, John T., Reynolds, Matthew R., Williams, K. Y., Klimentidis, Yann C., Wilson, Nancy A., Allison, David B., Rakasz, Eva G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863841/
https://ncbi.nlm.nih.gov/pubmed/20219903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02452-09
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