PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells

The direct infection of humans with highly pathogenic avian H5N1 influenza viruses has suggested viral mutation as one mechanism for the emergence of novel human influenza A viruses. Although the polymerase complex is known to be a key component in host adaptation, mutations that enhance the polymer...

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Bibliographische Detailangaben
Hauptverfasser: Bussey, Kendra A., Bousse, Tatiana L., Desmet, Emily A., Kim, Baek, Takimoto, Toru
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863787/
https://ncbi.nlm.nih.gov/pubmed/20181719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02642-09
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