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PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells

The direct infection of humans with highly pathogenic avian H5N1 influenza viruses has suggested viral mutation as one mechanism for the emergence of novel human influenza A viruses. Although the polymerase complex is known to be a key component in host adaptation, mutations that enhance the polymer...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bussey, Kendra A., Bousse, Tatiana L., Desmet, Emily A., Kim, Baek, Takimoto, Toru
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863787/
https://ncbi.nlm.nih.gov/pubmed/20181719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02642-09
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