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Lack of a Clinically Relevant Effect of an Antacid on the Pharmacokinetics of Lersivirine

Lersivirine (UK-453,061) is a next-generation nonnucleoside reverse transcriptase inhibitor that displays potent antiviral activity. Lersivirine solubility is pH dependent; therefore, the effect of coadministration of antacid on the pharmacokinetics of lersivirine in healthy subjects was investigate...

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Bibliografiske detaljer
Main Authors: Vourvahis, M., Banerjee, S., LaBadie, R., Gore, D., Mayer, H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863683/
https://ncbi.nlm.nih.gov/pubmed/20160047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01110-09
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