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Lack of a Clinically Relevant Effect of an Antacid on the Pharmacokinetics of Lersivirine

Lersivirine (UK-453,061) is a next-generation nonnucleoside reverse transcriptase inhibitor that displays potent antiviral activity. Lersivirine solubility is pH dependent; therefore, the effect of coadministration of antacid on the pharmacokinetics of lersivirine in healthy subjects was investigate...

詳細記述

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書誌詳細
主要な著者: Vourvahis, M., Banerjee, S., LaBadie, R., Gore, D., Mayer, H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863683/
https://ncbi.nlm.nih.gov/pubmed/20160047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01110-09
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