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Lack of a Clinically Relevant Effect of an Antacid on the Pharmacokinetics of Lersivirine
Lersivirine (UK-453,061) is a next-generation nonnucleoside reverse transcriptase inhibitor that displays potent antiviral activity. Lersivirine solubility is pH dependent; therefore, the effect of coadministration of antacid on the pharmacokinetics of lersivirine in healthy subjects was investigate...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology (ASM)
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863683/ https://ncbi.nlm.nih.gov/pubmed/20160047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01110-09 |
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