Persistent Interactions between Biguanide-Based Compound NB325 and CXCR4 Result in Prolonged Inhibition of Human Immunodeficiency Virus Type 1 Infection

We previously demonstrated that the biguanide-based compound NB325 inhibits human immunodeficiency virus type 1 (HIV-1) infection by interacting with the CXCR4 viral coreceptor. This interaction also appeared to be persistent, since HIV-1 infection was inhibited even when the virus was introduced su...

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Detalhes bibliográficos
Main Authors: Thakkar, Nina, Pirrone, Vanessa, Passic, Shendra, Keogan, Shawn, Zhu, Wei, Kholodovych, Vladyslav, Welsh, William, Rando, Robert, Labib, Mohamed, Wigdahl, Brian, Krebs, Fred C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863618/
https://ncbi.nlm.nih.gov/pubmed/20231400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00934-09
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