Specific Interactions between the Viral Coreceptor CXCR4 and the Biguanide-Based Compound NB325 Mediate Inhibition of Human Immunodeficiency Virus Type 1 Infection

The present studies were conducted to better define the mechanism of action of polyethylene hexamethylene biguanide (PEHMB) (designated herein as NB325), which was shown in previous studies to inhibit infection by the human immunodeficiency virus type 1 (HIV-1). Fluorescence-activated flow cytometri...

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Bibliografiske detaljer
Main Authors: Thakkar, Nina, Pirrone, Vanessa, Passic, Shendra, Zhu, Wei, Kholodovych, Vladyslav, Welsh, William, Rando, Robert F., Labib, Mohamed E., Wigdahl, Brian, Krebs, Fred C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630669/
https://ncbi.nlm.nih.gov/pubmed/19047650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00866-08
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