Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model

Colistin is increasingly being utilized against Gram-negative pathogens, including Pseudomonas aeruginosa, resistant to all other antibiotics. Since limited data exist regarding killing by colistin at different initial inocula (CFUo), we evaluated killing of Pseudomonas aeruginosa by colistin at sev...

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Bibliographic Details
Main Authors: Bulitta, Jürgen B., Yang, Jenny C., Yohonn, Liliana, Ly, Neang S., Brown, Silvia V., D'Hondt, Rebecca E., Jusko, William J., Forrest, Alan, Tsuji, Brian T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863601/
https://ncbi.nlm.nih.gov/pubmed/20211900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00881-09
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