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The Actinomycin Biosynthetic Gene Cluster of Streptomyces chrysomallus: a Genetic Hall of Mirrors for Synthesis of a Molecule with Mirror Symmetry

A gene cluster was identified which contains genes involved in the biosynthesis of actinomycin encompassing 50 kb of contiguous DNA on the chromosome of Streptomyces chrysomallus. It contains 28 genes with biosynthetic functions and is bordered on both sides by IS elements. Unprecedentedly, the clus...

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Autori principali: Keller, Ullrich, Lang, Manuel, Crnovcic, Ivana, Pfennig, Frank, Schauwecker, Florian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863554/
https://ncbi.nlm.nih.gov/pubmed/20304989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01526-09
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