Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in a PPARα-dependent Manner

Thyroid hormone has profound and diverse effects on liver metabolism. Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21). Mice treated with T3 showed a dose-dependent increase i...

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Bibliografiske detaljer
Main Authors: Adams, Andrew C., Astapova, Inna, Fisher, ffolliott M., Badman, Michael K., Kurgansky, Katherine E., Flier, Jeffrey S., Hollenberg, Anthony N., Maratos-Flier, Eleftheria
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863226/
https://ncbi.nlm.nih.gov/pubmed/20236931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.107375
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