Estrogen Inhibits Transforming Growth Factor β Signaling by Promoting Smad2/3 Degradation

Estrogen is a growth factor that stimulates cell proliferation. The effects of estrogen are mediated through the estrogen receptors, ERα and ERβ, which function as ligand-induced transcription factors and belong to the nuclear receptor superfamily. On the other hand, TGF-β acts as a cell growth inhi...

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Bibliographic Details
Main Authors: Ito, Ichiaki, Hanyu, Aki, Wayama, Mitsutoshi, Goto, Natsuka, Katsuno, Yoko, Kawasaki, Shohei, Nakajima, Yuka, Kajiro, Masashi, Komatsu, Yoko, Fujimura, Akiko, Hirota, Ryuichi, Murayama, Akiko, Kimura, Keiji, Imamura, Takeshi, Yanagisawa, Junn
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863224/
https://ncbi.nlm.nih.gov/pubmed/20207742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093039
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