Origin of the Allyl Group in FK506 Biosynthesis

FK506 (tacrolimus) is a secondary metabolite with a potent immunosuppressive activity, currently registered for use as immunosuppressant after organ transplantation. FK506 and FK520 are biogenetically related natural products that are synthesized by combined polyketide synthase/nonribosomal peptide...

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Detalhes bibliográficos
Principais autores: Goranovič, Dušan, Kosec, Gregor, Mrak, Peter, Fujs, Štefan, Horvat, Jaka, Kuščer, Enej, Kopitar, Gregor, Petković, Hrvoje
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863216/
https://ncbi.nlm.nih.gov/pubmed/20194504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059600
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