Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function

Mitogen-activated protein kinase kinase 3 (MAP2K3) is a member of the dual specificity kinase group. Growing evidence links MAP2K3 to invasion and tumor progression. Here, we identify MAP2K3 as a transcriptional target of endogenous gain-of-function p53 mutants R273H, R175H, and R280K. We show that...

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Hlavní autoři: Gurtner, Aymone, Starace, Giuseppe, Norelli, Giuseppe, Piaggio, Giulia, Sacchi, Ada, Bossi, Gianluca
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863202/
https://ncbi.nlm.nih.gov/pubmed/20223820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094813
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