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DNase I Hypersensitivity and ϵ-Globin Transcriptional Enhancement Are Separable in Locus Control Region (LCR) HS1 Mutant Human β-Globin YAC Transgenic Mice
Expression of the five β-like globin genes (ϵ, Gγ, Aγ, δ, β) in the human β-globin locus depends on enhancement by the locus control region, which consists of five DNase I hypersensitive sites (5′HS1 through 5′HS5). We report here a novel enhancer activity in 5′HS1 that appears to be potent in trans...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863201/ https://ncbi.nlm.nih.gov/pubmed/20231293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116525 |
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