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Unraveling the Specificity of Heparanase Utilizing Synthetic Substrates
Heparanase is a promising anticancer target because of its involvement in cancer invasion and metastasis. Heparanase cleaves heparan sulfate (HS), a sulfated polysaccharide, and activates a series of HS-mediated cell proliferation and angiogenesis processes. Understanding the substrate specificity o...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863188/ https://ncbi.nlm.nih.gov/pubmed/20181948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104166 |
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