Inhibition of Acyl-Coenzyme A:Cholesterol Acyltransferase 2 (ACAT2) Prevents Dietary Cholesterol-associated Steatosis by Enhancing Hepatic Triglyceride Mobilization

Acyl-CoA:cholesterol O-acyl transferase 2 (ACAT2) promotes cholesterol absorption by the intestine and the secretion of cholesteryl ester-enriched very low density lipoproteins by the liver. Paradoxically, mice lacking ACAT2 also exhibit mild hypertriglyceridemia. The present study addresses the une...

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Bibliographic Details
Main Authors: Alger, Heather M., Brown, J. Mark, Sawyer, Janet K., Kelley, Kathryn L., Shah, Ramesh, Wilson, Martha D., Willingham, Mark C., Rudel, Lawrence L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863169/
https://ncbi.nlm.nih.gov/pubmed/20231283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118422
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