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β1-Integrin-Collagen Interaction Suppresses FoxO3a by the Coordination of Akt and PP2A
When cells attach to the extracellular matrix (ECM) a proliferation permissive signal is engaged. The mechanism involves activation of the integrin/PI3K/Akt signal pathway. FoxO3a is a transcriptional activator and inhibits cell proliferation via up-regulating the expression of the cell cycle inhibi...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863165/ https://ncbi.nlm.nih.gov/pubmed/20223831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.052845 |
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