Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.

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Bibliographic Details
Main Authors:	Oskarsson, Thordur, Nagorny, Pavel, Krauss, Isaac, Perez, Lucy, Mandal, Mihiribaran, Yang, Guangli, Ouerfelli, Ouathek, Xiao, Danhua, Moore, Malcolm, Massagué, Joan, Danishefsky, Samuel J.
Format:	Artigo
Language:	Inglês
Published:	2010
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2863049/ https://ncbi.nlm.nih.gov/pubmed/20155906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9101503
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Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

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